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PectaSol Modified Citrus Pectin Powder Super-Nutrient to Support Cellular & Immune Health, Joint Support - 454 Grams - Formulated by Dr. Isaac Eliaz of ecoNugenics

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Cho, Y., Turner, N. D., Davidson, L. A., Chapkin, R. S., Carroll, R. J., and Lupton, J. R. (2012). A chemoprotective fish oil/pectin diet enhances apoptosis via Bcl-2 promoter methylation in rat azoxymethane-induced carcinomas. Exp. Biol. Med. (Maywood) 237, 1387–1393. doi: 10.1258/ebm.2012.012244

Letter to the Editor: Not all modified citrus pectins are the

One promising study of 49 patients with advanced solid tumors found that MCP stabilized cancer progression and improved quality of life with no severe side effects [ 8]. Those in the pilot study were given MCP three times a day for two months. ProstaCaid® — The combination of PectaSol with ProstaCaid provides up to 40% greater benefits for prostate cellular health, compared to using either product alone.*

Modified Citrus Pectin Supports a Healthy Immune Response

Modified citrus pectin was mainly studied in Avraham Raz’s laboratory and has shown strong anti-cancer activities. Injection of pectin increased the number of tumors detected in lung after B16-F1 melanoma cells implantation in C57BL/6 mice probably by increasing homotypic aggregation between tumor cells while MCP significantly diminished the number of metastases. MCP which is rich in galactoside residues seems to impair cell-cell interactions by competing with endogenous ligands of “galactoside binding proteins” and more particularly of galectin-3 ( Platt and Raz, 1992; Inohara and Raz, 1994). Raz’s team also showed that orally administered MCP decreased the number of metastases in lung in rats injected with prostate cancer MAT-LyLu cells. This decrease was dose-dependent ( Pienta et al., 1995). In 2002, they also evidenced that MCP decreased the growth of breast (MDA-MB-435) and colon (LSLiM6) tumors implanted in NRC nu/nu mice as well as the number of metastases in lung and lymph nodes. These effects were associated with anti-angiogenic effects since a decrease in the number of capillaries in vivo and an inhibition of tubulogenesis in vitro using HUVEC were observed ( Nangia-Makker et al., 2002). Other works have also evidenced the anti-tumor activity of MCP. When added to the culture medium of prostate androgen-independent JCA-1 tumor cells, MCP diminished proliferation and tritiated thymidine incorporation. MCP decreased the expression of nm23, a protein whose expression is inversely correlated with metastasis in various cancers ( Hsieh and Wu, 1995). Hayashi et al. (2000) showed that oral daily doses of 0.8 and 1.6 mg/ml MCP to Balb-C mice implanted with colon tumors decreased tumor size, of respectively 38 and 70%. GCS-100, which is a commercially available form of modified pectin, has been shown to be efficient against different lines of multiple myelomas some of them resistant to chemotherapy, by inducing caspase-3 and -8 activation as well as PARP cleavage. Modified pectin-induced apoptosis was partly inhibited by Z-VAD-fmk, a pan-caspase inhibitor ( Chauhan et al., 2005). A phase II clinical study on prostate cancer patients showed that PectaSol® MCP significantly increased PSADT (PSA doubling time) in 7 out of the 10 cases included in this study ( Guess et al., 2003). PectaSol® and its ameliorated version PectaSol-C® are cytotoxic for different cancer cell lines: LNCaP, PC3, CASP2.1, CASP1.1, and BPH-1. In CASP1.1 and PC3 cells, cytotoxicity was correlated with MAP kinase activation inhibition, increased Bim protein expression and caspase-3 cleavage ( Yan and Katz, 2010). This product also inhibits the invasive behavior of human breast and prostate cancer cells in vitro ( Jiang et al., 2013). Our team of licensed nutritionists and dietitians strive to be objective, unbiased, honest and to present both sides of the argument. Gao, X., Zhi, Y., Zhang, T., Xue, H., Wang, X., Foday, A. D., et al. (2012). Analysis of the neutral polysaccharide fraction of MCP and its inhibitory activity on galectin-3. Glycoconj. J. 29, 159–165. doi: 10.1007/s10719-012-9382-5

PectaSol Modified Citrus Pectin Powder Super-Nutrient to PectaSol Modified Citrus Pectin Powder Super-Nutrient to

There were also no negative side effects observed in a clinical trial involving children with lead toxicity in China. For three months, the hospitalized children between the ages of 5 and 12 were given 15 g of MCP in three divided doses a day [ 4]. L. Calvier, et al., “The Impact of Galectin-3 Inhibition on Aldosterone-Induced Cardiac and Renal Injuries,” JACC Heart Fail. 3(1), 59–67 (2015). B.W. Guess, et al., “Modified Citrus Pectin (MCP) Increases the Prostate-Specific Antigen Doubling Time in Men with Prostate Cancer: A Phase II Pilot Study,” Prostate Cancer Prostatic Dis. 6(4), 301–304 (2003).Hayashi, A., Gillen, A. C., and Lott, J. R. (2000). Effects of daily oral administration of quercetin chalcone and modified citrus pectin on implanted colon-25 tumor growth in Balb-c mice. Altern. Med. Rev. 5, 546–552.

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